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Home / Primary Antibodies / IHC Antibodies

GUCY1B3 Antibody

SKU : BHA10559187

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA214476
Alternative Names	4.6.1.2; GC-S-beta-1; GC-SB3; GUC1B3; GUCB3
Categories	Primary Antibodies
Clonality	polyclonal
Description	This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants.A. Shimouchi, Am J Physiol Lung Cell Mol Physiol, Nov 1993; 265: 456.Peter Sinnaeve, Circ. Res., Jan 2001; 88: 103.Stephan Thelitz, J. Thorac. Cardiovasc. Surg., May 2004; 127: 1285 - 1292.Richard C. Venema, Am J Physiol Heart Circ Physiol, Jul 2003; 2
Host	Rabbit
Immunogen	Synthesized peptide derived from Human Guanylate Cyclase β.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants. A. Shimouchi, Am J Physiol Lung Cell Mol Physiol, Nov 1993; 265: 456. Peter Sinnaeve, Circ. Res., Jan 2001; 88: 103. Stephan Thelitz, J. Thorac. Cardiovasc. Surg., May 2004; 127: 1285 - 1292. Richard C. Venema, Am J Physiol Heart Circ Physiol, Jul 2003; 2
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total Guanylate Cyclase β protein.
Subcellular Location	Cytoplasm

Uniprot	Q02153
Database Links	HGNC:4687 OMIM:139397 KEGG:hsa:2983 STRING:9606.ENSP00000264424 UniGene:Hs.77890
Function	Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP.
Pathway	Gap junction Vascular smooth muscle contraction cGMP-PKG signaling pathway
Protein Families	Adenylyl cyclase class-4/guanylyl cyclase family
Tissue Specificity	Detected in brain cortex and cerebellum (at protein level).

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC, IF

Description

ELISA ; WB ; IHC ; IF, WB ; ELISA ; IHC ; IF

Dilution

WB	1:500-1:3000
IHC	1:50-1:200
IF	1:100-1:200

Tested Application

ELISA,WB,IHC,IF;WB:1:500-1:3000,IHC:1:50-1:200,IF:1:100-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559187	CSB-PA214476	100ul	$297		Add to Cart

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