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Home / Primary Antibodies / IHC Antibodies

GEMIN2 Antibody

SKU : BHA10554464

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA871262
Alternative Names	gem (nuclear organelle) associated protein 2
Categories	Primary Antibodies
Description	This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration.
Host	Rabbit
Immunogen	Synthetic peptide of human GEMIN2
Isotype	IgG
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration.
Species	Homo Sapiens (Human)
Subcellular Location	Nucleus, gem, Cytoplasm

Uniprot	O14893
Database Links	HGNC:10884 OMIM:602595 KEGG:hsa:8487 STRING:9606.ENSP00000308533 UniGene:Hs.652307
Function	The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.
Protein Families	Gemin-2 family

Buffer	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form	Liquid
Format	Liquid
Purification	Antigen affinity purification
Purity	Antigen affinity purification
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

ELISA	1:1000-1:5000
WB	1:200-1:1000
IHC	1:50-1:200

Tested Application

ELISA,WB,IHC;ELISA:1:1000-1:5000,WB:1:200-1:1000,IHC:1:50-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10554464	CSB-PA871262	100ul	$299		Add to Cart
BHA10554464	CSB-PA871262	50ul	$166		Add to Cart

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