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Home / Primary Antibodies / IHC Antibodies

G6PD Antibody

SKU : BHA10557221

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA009121KA01HU
Alternative Names	G6PD; G6PD1
Categories	Primary Antibodies
Description	Glucose-6-phosphate dehydrogenase (G6PD) catalyses the first and rate-limiting step of the pentose phosphate pathway. The NADPH generated from this reaction is essential to protect cells from oxidative stress. Recent studies have shown that p53 interacts with G6PD and inhibits its activity, therefore suppressing glucose consumption through the pentose phosphate pathway. In cancer cells with p53 mutations, the increased glucose consumption is directed towards increased biosynthesis, which is critical for cancer cell proliferation.
Hgnc	4057
Host	Rabbit
Immunogen	Recombinant protein of Human G6PD, Recombinant protein of Human G6PD
Intended Use	For research use only. Not for human, diagnostic or therapeutic use.
Involvement In Disease	Anemia, non-spherocytic hemolytic, due to G6PD deficiency (NSHA)
Isotype	IgG
Mgi	105979, 105979
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Glucose-6-phosphate dehydrogenase (G6PD) catalyses the first and rate-limiting step of the pentose phosphate pathway. The NADPH generated from this reaction is essential to protect cells from oxidative stress. Recent studies have shown that p53 interacts with G6PD and inhibits its activity, therefore suppressing glucose consumption through the pentose phosphate pathway. In cancer cells with p53 mutations, the increased glucose consumption is directed towards increased biosynthesis, which is critical for cancer cell proliferation.
Size	100μl(100μg)
Species	Homo Sapiens (Human)

Rgd	2645, 2645
Target Details	This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene.
Uniprot	P11413
Database Links	HGNC:4057 OMIM:300908 KEGG:hsa:2539 STRING:9606.ENSP00000377192 UniGene:Hs.461047
Function	Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.
Protein Families	Glucose-6-phosphate dehydrogenase family
Tissue Specificity	Isoform Long is found in lymphoblasts, granulocytes and sperm.

Buffer	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Format	liquid
Purification	Affinity purification
Purity	Affinity purification
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA

Dilution

WB	1:500-1:2000
IHC	1:50-1:200

,

WB	1:500-1:2000
IHC	1:50-1:200

Tested Application

ELISA,WB;WB:1:500-1:2000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557221	CSB-PA009121KA01HU	100ul	$398		Add to Cart

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