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Home / Primary Antibodies / IHC Antibodies

FOXO1 (Ab-256) Antibody

SKU : BHA10559631

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA228665
Alternative Names	FOXO1
Categories	Primary Antibodies
Clonality	polyclonal
Description	FKHR belongs to the forkhead family of transcription factors, which are characterized by a distinct forkhead domain. It may play a role in myogenic growth and differentiation. The mammalian DAF-16-like transcription factors, FKHR, FKHRL1, and AFX, function as key regulators of insulin signaling, cell cycle progression, and apoptosis downstream of phosphoinositide 3-kinase. Gene activation through binding to insulin response sequences has been essential for mediating these functions. D-type Cyclins (in Class III) is required for FKHR mediated inhibition of cell cycle progression and transformation. FKHR gene is mapped to chromosome 13q14 Gan L, et al. (2005) J Neurochem; 93(5): 1209-19. Smith WW, et al. (2005) J Cell Biol; 169(2): 331-9. Di Maira G, et al. (2005) Cell Death Differ; 12(6): 668-77. Horn S, et al. (2004) Leukemia; 18(11): 1839-49. Zhao X, et al. (2004) Biochem J 4; 378(Pt 3): 839-49.
Host	Rabbit
Immunogen	Peptide sequence around aa.254~258 (A-A-S-M-D) derived from Human FKHR/FOXO1A.
Involvement In Disease	Rhabdomyosarcoma 2 (RMS2)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	FKHR belongs to the forkhead family of transcription factors, which are characterized by a distinct forkhead domain. It may play a role in myogenic growth and differentiation. The mammalian DAF-16-like transcription factors, FKHR, FKHRL1, and AFX, function as key regulators of insulin signaling, cell cycle progression, and apoptosis downstream of phosphoinositide 3-kinase. Gene activation through binding to insulin response sequences has been essential for mediating these functions. D-type Cyclins (in Class III) is required for FKHR mediated inhibition of cell cycle progression and transformation. FKHR gene is mapped to chromosome 13q14 Gan L, et al. (2005) J Neurochem; 93(5): 1209-19. Smith WW, et al. (2005) J Cell Biol; 169(2): 331-9. Di Maira G, et al. (2005) Cell Death Differ; 12(6): 668-77. Horn S, et al. (2004) Leukemia; 18(11): 1839-49. Zhao X, et al. (2004) Biochem J 4; 378(Pt 3): 839-49.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of total FKHR protein.
Subcellular Location	Cytoplasm, Nucleus

Uniprot	Q12778
Database Links	HGNC:3819 OMIM:136533 KEGG:hsa:2308 STRING:9606.ENSP00000368880 UniGene:Hs.370666
Function	Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1. Promotes neural cell death. Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner. Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity).
Pathway	Cellular senescence AGE-RAGE signaling pathway in diabetic complications AMPK signaling FoxO signaling pathway Glucagon signaling pathway Insulin signaling pathway
Tissue Specificity	Ubiquitous.

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC, IF

Description

ELISA ; WB ; IHC ; IF, WB ; ELISA ; IHC ; IF

Dilution

WB	1:500-1:1000
IHC	1:50-1:200
IF	1:100-1:200

Tested Application

ELISA,WB,IHC,IF;WB:1:500-1:1000,IHC:1:50-1:200,IF:1:100-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559631	CSB-PA228665	100ul	$297		Add to Cart

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