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Home / Primary Antibodies / IHC Antibodies

FOS Antibody

SKU : BHA10557376

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA138717
Alternative Names	activator protein 1; AP-1; C-FOS; cellular oncogene c-fos; Cellular oncogene fos; FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS); FBJ murine osteosarcoma viral oncogene homolog; FOS; G0/G1 switch regulatory protein 7; G0S7; Proto-o
Categories	Primary Antibodies
Clonality	polyclonal
Description	The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death."
Host	Rabbit
Immunogen	A synthesized peptide derived from Human Fos
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. "
Species	Homo Sapiens (Human)
Specificity	Fos antibody detects endogenous levels of total Fos.
Subcellular Location	Nucleus, Endoplasmic reticulum, Cytoplasm, cytosol

Uniprot	P01100
Database Links	HGNC:3796 OMIM:164810 KEGG:hsa:2353 STRING:9606.ENSP00000306245 UniGene:Hs.25647
Function	Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.
Pathway	cAMP signaling pathway Estrogen signaling pathway MAPK signaling pathway TNF signaling pathway Apoptosis B cell receptor signaling pathway IL-17 signaling pathway Osteoclast differentiation T cell receptor signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation Toll-like receptor signaling pathway
Protein Families	BZIP family, Fos subfamily

Buffer	Rabbit IgG in phosphate buffered saline , pH7.4, 150mM NaCl, 0.02% sodium azide and50% glycerol.
Form	Rabbit IgG in phosphate buffered saline , pH7.4, 150mM NaCl, 0.02% sodium azide and50% glycerol.
Format	liquid
Purification	Affinity-chromatography
Purity	Affinity-chromatography
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:2000
IHC	1:50-1:200

Tested Application

ELISA,WB,IHC;WB:1:500-1:2000,IHC:1:50-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557376	CSB-PA138717	100ul	$295		Add to Cart

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