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Home / Primary Antibodies / IHC Antibodies

FASLG Antibody

SKU : BHA10559728

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA243242
Alternative Names	Tumor necrosis factor ligand superfamily member 6; Fas antigen ligand; Fas ligand; CD178 antigen; CD95L protein
Categories	Primary Antibodies
Clonality	polyclonal
Description	Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects. The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition.Alderson M.; J. Exp. Med. 181:71-77(1995).Takahashi T., Int. Immunol. 6:1567-1574(1994).Gregory S.G., ure 441:315-321(2006).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human FAS ligand.
Involvement In Disease	Autoimmune lymphoproliferative syndrome 1B (ALPS1B)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects. The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition. Alderson M.; J. Exp. Med. 181:71-77(1995). Takahashi T., Int. Immunol. 6:1567-1574(1994). Gregory S.G., ure 441:315-321(2006).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total FAS ligand protein.
Subcellular Location	Cell membrane, Single-pass type II membrane protein, Cytoplasmic vesicle lumen, Lysosome lumen, Note=Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination (PubMed:17164290), Colocalizes with the SPPL2A protease at the cell membrane (PubMed:17557115), SUBCELLULAR LOCATION: Tumor necrosis factor ligand superfamily member 6, soluble form: Secreted, Note=May be released into the extracellular fluid by cleavage from the cell surface, SUBCELLULAR LOCATION: FasL intracellular domain: Nucleus

Uniprot	P48023
Database Links	HGNC:11936 OMIM:134638 KEGG:hsa:356 STRING:9606.ENSP00000356694 UniGene:Hs.2007
Function	Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells
Pathway	MAPK signaling pathway PI3K-Akt signaling pathway Apoptosis Necroptosis Ras signaling pathway Natural killer cell mediated cytotoxicity FoxO signaling pathway Neurotrophin signaling pathway
Protein Families	Tumor necrosis factor family

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:3000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:3000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559728	CSB-PA243242	100ul	$297		Add to Cart

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