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Home / Primary Antibodies / IHC Antibodies

ERBB3 Antibody

SKU : BHA10559169

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA259090
Alternative Names	c-erbB3; EC 2.7.10.1; ERB3; ERBB3; HER3
Categories	Primary Antibodies
Clonality	polyclonal
Description	Binds and is activated by neuregulins and NTAK.Kraus M.H., Proc. Natl. Acad. Sci. U.S.A. 86:9193-9197(1989).Plowman G.D., Proc. Natl. Acad. Sci. U.S.A. 87:4905-4909(1990).Katoh M., Biochem. Biophys. Res. Commun. 192:1189-1197(1993).
Host	Rabbit
Immunogen	Synthesized peptide derived from N-terminal of Human HER3.
Involvement In Disease	Lethal congenital contracture syndrome 2 (LCCS2)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Binds and is activated by neuregulins and NTAK. Kraus M.H., Proc. Natl. Acad. Sci. U.S.A. 86:9193-9197(1989). Plowman G.D., Proc. Natl. Acad. Sci. U.S.A. 87:4905-4909(1990). Katoh M., Biochem. Biophys. Res. Commun. 192:1189-1197(1993).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total HER3 protein.
Subcellular Location	Isoform 1: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 2: Secreted

Uniprot	P21860
Database Links	HGNC:3431 OMIM:190151 KEGG:hsa:2065 STRING:9606.ENSP00000267101 UniGene:Hs.118681
Function	Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase
Pathway	Calcium signaling pathway ErbB signaling pathway MAPK signaling pathway PI3K-Akt signaling pathway
Protein Families	Protein kinase superfamily, Tyr protein kinase family, EGF receptor subfamily
Tissue Specificity	Epithelial tissues and brain.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:3000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:3000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559169	CSB-PA259090	100ul	$297		Add to Cart

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