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Home / Primary Antibodies / IHC Antibodies

EGFR (Ab-1172) Antibody

SKU : BHA10559699

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA579851
Alternative Names	EC 2.7.10.1; epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog; avian); Epidermal growth factor receptor precursor; ERBB1
Categories	Primary Antibodies
Clonality	polyclonal
Description	Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Isoform 2 may act as an antagonist of EGF action.Ullrich A., Nature 309:418-425(1984).Ilekis J.V., Mol. Reprod. Dev. 41:149-156(1995).Reiter J.L., Nucleic Acids Res. 24:4050-4056(1996)
Host	Rabbit
Immunogen	Synthesized non-phosphopeptide derived from Human EGFR around the phosphorylation site of tyrosine 1172 (P-D-Y(p)-Q-Q).
Involvement In Disease	Lung cancer (LNCR); Inflammatory skin and bowel disease, neonatal, 2 (NISBD2)
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Isoform 2 may act as an antagonist of EGF action. Ullrich A., Nature 309:418-425(1984). Ilekis J.V., Mol. Reprod. Dev. 41:149-156(1995). Reiter J.L., Nucleic Acids Res. 24:4050-4056(1996)
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total EGFR protein.
Subcellular Location	Cell membrane, Single-pass type I membrane protein, Endoplasmic reticulum membrane, Single-pass type I membrane protein, Golgi apparatus membrane, Single-pass type I membrane protein, Nucleus membrane, Single-pass type I membrane protein, Endosome, Endosome membrane, Nucleus

Uniprot	P00533
Database Links	HGNC:3236 OMIM:131550 KEGG:hsa:1956 STRING:9606.ENSP00000275493 UniGene:Hs.488293
Function	Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Plays a role in enhancing learning and memory performance (By similarity).
Pathway	Calcium signaling pathway ErbB signaling pathway Estrogen signaling pathway HIF-1 signaling pathway Jak-STAT signaling pathway MAPK signaling pathway PI3K-Akt signaling pathway Focal adhesion Gap junction Regulation of actin cytoskeleton Adherens junction Ras signaling pathway FoxO signaling pathway Phospholipase D signaling pathway Rap1 signaling pathway Endocytosis
Protein Families	Protein kinase superfamily, Tyr protein kinase family, EGF receptor subfamily
Tissue Specificity	Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC, IF

Description

ELISA ; WB ; IHC ; IF, WB ; ELISA ; IHC ; IF

Dilution

WB	1:500-1:3000
IHC	1:50-1:100
IF	1:100-1:500

Tested Application

ELISA,WB,IHC,IF;WB:1:500-1:3000,IHC:1:50-1:100,IF:1:100-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559699	CSB-PA579851	100ul	$297		Add to Cart

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