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Home / Primary Antibodies / IHC Antibodies

E2F6 Antibody

SKU : BHA10559723

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA945555
Alternative Names	E2F-6; E2F transcription factor 6 isoform 1; E2F transcription factor 6 isoform 2; E2F transcription factor 6 isoform 3; E2F transcription factor 6 isoform 4
Categories	Primary Antibodies
Clonality	polyclonal
Description	Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase.Matthew J. Oberley, J. Biol. Chem., Oct 2003; 278: 42466 - 42476.Claire Attwooll, J. Biol. Chem., Jan 2005; 280: 1199 - 1208.Paloma H. Giangrande, Genes & Dev., Dec 2004; 18: 2941 - 2951.J rg Storre, J. Biol. Chem., Dec 2005; 280: 41380 - 41386.
Host	Rabbit
Immunogen	Synthesized peptide derived from Human E2F6.
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase. Matthew J. Oberley, J. Biol. Chem., Oct 2003; 278: 42466 - 42476. Claire Attwooll, J. Biol. Chem., Jan 2005; 280: 1199 - 1208. Paloma H. Giangrande, Genes & Dev., Dec 2004; 18: 2941 - 2951. J?rg Storre, J. Biol. Chem., Dec 2005; 280: 41380 - 41386.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total E2F6 protein.
Subcellular Location	Nucleus

Uniprot	O75461
Database Links	HGNC:3120 OMIM:602944 KEGG:hsa:1876 STRING:9606.ENSP00000370936 UniGene:Hs.603093
Function	Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase.
Protein Families	E2F/DP family
Tissue Specificity	Expressed in all tissues examined. Highest levels in placenta, skeletal muscle, heart, ovary, kidney, small intestine and spleen.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:3000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:3000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559723	CSB-PA945555	100ul	$297		Add to Cart

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