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Home / Primary Antibodies / IHC Antibodies

DGKH Antibody

SKU : BHA10559334

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA054492
Alternative Names	iacylglycerol kinase eta; EC 2.7.1.107; Diglyceride kinase eta; DGK-eta; DAG kinase eta
Categories	Primary Antibodies
Clonality	polyclonal
Description	Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization.Murakami T., J. Biol. Chem. 278:34364-34372(2003) .Dunham A., Nature 428:522-528(2004). Ota T., Nat. Genet. 36:40-45(2004).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human DGKH.
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization. Murakami T., J. Biol. Chem. 278:34364-34372(2003) . Dunham A., Nature 428:522-528(2004). Ota T., Nat. Genet. 36:40-45(2004).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total DGKH protein
Subcellular Location	Cytoplasm, Cell membrane

Uniprot	Q86XP1
Database Links	HGNC:2854 OMIM:604071 KEGG:hsa:160851 STRING:9606.ENSP00000337572 UniGene:Hs.630380
Function	Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization.
Pathway	Oxidative Phosphorylation Phosphatidylinositol signaling system Phospholipase D signaling pathway
Protein Families	Eukaryotic diacylglycerol kinase family
Tissue Specificity	Isoform 2 is ubiquitously expressed. Isoform 1 is expressed only in testis, kidney and colon.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, IHC, IF

Description

ELISA ; IHC ; IF, IF ; ELISA ; IHC

Dilution

IHC	1:50-1:100
IF	1:100-1:500

Tested Application

ELISA,IHC,IF;IHC:1:50-1:100,IF:1:100-1:500

Datasheet
ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559334	CSB-PA054492	100ul	$297		Add to Cart

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