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Home / Primary Antibodies / IHC Antibodies

DAB1 (Ab-232) Antibody

SKU : BHA10557479

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA907168
Alternative Names	Disabled homolog 1
Categories	Primary Antibodies
Clonality	polyclonal
Description	The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.Kelian Chen, et,al. (2003) J. Cell Sci 117: 4527 - 4536.Vera Strasser, et,al. (2004) Mol. Cell. Biol 24: 1378 - 1386.Izhar Ben-Shlomo, et,al. (2003) Sci. STKE 2003: 9.H. M. Kim, et,al. (2002) PNAS 99: 4020.
Host	Rabbit
Immunogen	Peptide sequence around aa.230~234 (G-V-Y-D-V) derived from Human Dab1.
Involvement In Disease	Spinocerebellar ataxia 37 (SCA37)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. Kelian Chen, et,al. (2003) J. Cell Sci ; 117: 4527 - 4536. Vera Strasser, et,al. (2004) Mol. Cell. Biol ; 24: 1378 - 1386. Izhar Ben-Shlomo, et,al. (2003) Sci. STKE ; 2003: 9. H. M. Kim, et,al. (2002) PNAS ; 99: 4020.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of total Dab1 protein.

Uniprot	O75553
Database Links	HGNC:2661 OMIM:603448 KEGG:hsa:1600 UniGene:Hs.477370
Function	Adapter molecule functioning in neural development. May regulate SIAH1 activity.
Tissue Specificity	Mainly expressed in brain.

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, IHC

Description

ELISA ; IHC, IHC ; ELISA

Dilution

IHC	1:50-1:100

Tested Application

ELISA,IHC;IHC:1:50-1:100

Datasheet
ELISA Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557479	CSB-PA907168	100ul	$297		Add to Cart

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