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Home / Primary Antibodies / IHC Antibodies

Cleaved-CASP3 (A175) Antibody

SKU : BHA10557386

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA148736
Alternative Names	Apopain precursor; CASP-3; CPP-32; CPP32; Caspase-3; Cysteine protease CPP32; ICE3; SCA-1; SREBP cleavage activity 1; Yama protein,p17
Categories	Primary Antibodies
Clonality	polyclonal
Description	This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme."
Host	Rabbit
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme.
Species	Homo Sapiens (Human)
Specificity	Caspase 3 (p17,Cleaved-Asp175) Antibody detects endogenous levels of fragment of activated Caspase 3 resulting from cleavage adjacent to Asp175.
Subcellular Location	Cytoplasm

Uniprot	P42574
Gene Id	836
Database Links	HGNC:1504 OMIM:600636 KEGG:hsa:836 STRING:9606.ENSP00000311032 UniGene:Hs.141125
Function	Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp- ; -Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.
Pathway	MAPK signaling pathway p53 signaling pathway TNF signaling pathway Apoptosis IL-17 signaling pathway Natural killer cell mediated cytotoxicity AGE-RAGE signaling pathway in diabetic complications ER Stress pathway
Protein Families	Peptidase C14A family
Tissue Specificity	Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.
Weight	17kd

Buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Liquid
Format	liquid
Purification	Antigen Affinity Purified
Purity	Antigen Affinity Purified
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:2000
IHC	1:50-1:200
ICC	1:100-1:500
IF	1:100-1:500

Tested Application

ELISA, WB, IHC; WB:1:500-1:2000, IHC:1:50-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557386	CSB-PA148736	100ul	$295		Add to Cart

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