Plays a major role in tight junction-specific obliteration of the intercellular space By similarity.Michele D. Alexandre, J. Cell Sci., Jun 2005; 118: 2683 - 2693.Mercedes Lioni, Am. J. Pathol., Feb 2007; 170: 709 - 721.Hiroki Fujita, J. Histochem. Cytochem., Aug 2006; 54: 933 - 944.Wing Y. Li, Am J Physiol Renal Physiol, Jun 2004; 286: F1063 - F1071
Host
Rabbit
Immunogen
Synthesized peptide derived from Human Claudin 7.
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Plays a major role in tight junction-specific obliteration of the intercellular space By similarity.
Michele D. Alexandre, J. Cell Sci., Jun 2005; 118: 2683 - 2693. Mercedes Lioni, Am. J. Pathol., Feb 2007; 170: 709 - 721. Hiroki Fujita, J. Histochem. Cytochem., Aug 2006; 54: 933 - 944. Wing Y. Li, Am J Physiol Renal Physiol, Jun 2004; 286: F1063 - F1071
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total Claudin 7 protein.
Plays a major role in tight junction-specific obliteration of the intercellular space.
Protein Families
Claudin family
Tissue Specificity
Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (L
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.