Plays a major role in tight junction-specific obliteration of the intercellular space By similarity.Keen T.J.; Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.Kalnine N., Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.The MGC Project Team; Genome Res. 14:2121-2127(2004).
Host
Rabbit
Immunogen
Synthesized non-phosphopeptide derived from Human Claudin 7 around the phosphorylation site of tyrosine 210 (S-K-E-Y(p)-V).
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
Plays a major role in tight junction-specific obliteration of the intercellular space By similarity.
Keen T.J.; Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases. Kalnine N., Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. The MGC Project Team; Genome Res. 14:2121-2127(2004).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total Claudin 7 protein.
Plays a major role in tight junction-specific obliteration of the intercellular space.
Protein Families
Claudin family
Tissue Specificity
Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (L
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.