Cholesteryl ester transfer protein (CETP) is a circulating metabolic enzyme that transports cholesterol from the arteries to the liver. CETP converts cholesteryl esters from antiatherogenic high density lipoproteins (HDLs) to proatherogenic apolipoprotein B (apoB)-containing lipoproteins, including very low-, intermediate-, and low-DLs. Efficient transfer and exchange of cholesteryl esters and triglycerides between the lipoprotein classes of human plasma is necessary to maintain healthy arteries.
For research use only. Not for human, diagnostic or therapeutic use.
Involvement In Disease
Hyperalphalipoproteinemia 1 (HALP1)
Isotype
IgG
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Cholesteryl ester transfer protein (CETP) is a circulating metabolic enzyme that transports cholesterol from the arteries to the liver. CETP converts cholesteryl esters from antiatherogenic high density lipoproteins (HDLs) to proatherogenic apolipoprotein B (apoB)-containing lipoproteins, including very low-, intermediate-, and low-DLs. Efficient transfer and exchange of cholesteryl esters and triglycerides between the lipoprotein classes of human plasma is necessary to maintain healthy arteries.
Size
100μl(100μg)
Species
Homo Sapiens (Human)
Subcellular Location
Secreted, extracellular space
Antigen
CETP
Target Details
Cholesteryl ester transfer protein (CETP) transfers cholesteryl esters between lipoproteins. CETP may effect susceptibility to atherosclerosis.
Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL
Pathway
Cholesterol metabolism
Protein Families
BPI/LBP/Plunc superfamily, BPI/LBP family
Tissue Specificity
Expressed by the liver and secreted in plasma.
Buffer
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Format
liquid
Purification
Affinity purification
Purity
Affinity purification
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer
Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.