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Home / Primary Antibodies / IHC Antibodies

APOBEC3G Antibody

BHA10557212
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Target Details This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. This protein has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity.
Uniprot Q9HC16
Gene Id 60489
Database Links

HGNC:17357

OMIM:607113

KEGG:hsa:60489

STRING:9606.ENSP00000385057

UniGene:Hs.660143
Function DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits potent antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity also against simian immunodeficiency viruses (SIVs), hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV). May inhibit the mobility of LTR and non-LTR retrotransposons.
Protein Families Cytidine and deoxycytidylate deaminase family
Tissue Specificity Expressed in spleen, testes, ovary and peripheral blood leukocytes and CD4+ lymphocytes. Also expressed in non-permissive peripheral blood mononuclear cells, and several tumor cell lines; no expression detected in permissive lymphoid and non-lymphoid cell
Weight 46 kDa
Buffer Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Format liquid
Purification Affinity purification
Purity Affinity purification
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer

Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Applications ELISA, WB, IHC
Description ELISA ; WB ; IHC, WB ; ELISA ; IHC
Dilution

WB1:500-1:2000
IHC1:50-1:200
Tested Application ELISA,WB,IHC;WB:1:500-1:2000,IHC:1:50-1:200
Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
SKU Supplier No. Size Your price Quantity
BHA10557212 CSB-PA001926KA01HU 100μl $387.33
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