Metallocarboxypeptidase involved in the detyrosination of alpha-tubulin C-terminus.Ota T., Nat. Genet. 36:40-45(2004).Suzuki Y., Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.Taylor T.D., Nature 440:497-500(2006).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human CBCP2.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Metallocarboxypeptidase involved in the detyrosination of alpha-tubulin C-terminus.
Ota T., Nat. Genet. 36:40-45(2004). Suzuki Y., Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases. Taylor T.D., Nature 440:497-500(2006).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total CBCP2 protein.
Subcellular Location
Cytoplasm, cytosol, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole, Cytoplasm, cytoskeleton, cilium basal body
Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of tubulin.
Protein Families
Peptidase M14 family
Weight
104,194 Da
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.