Anti-CD63 Antibody BHA10206787

Mfr.No.	967-MSM5-P1ABX
Alternative Names	gp55 ; granulophysin ; Lysosomal-associated membrane protein 3 (LAMP-3) ; Mast cell antigen AD1 ; melanoma 1 antigen ; Melanoma-associated antigen MLA1 ; Melanoma-associated antigen ME491 ; MLA1 ; NGA ; Ocular melanoma-associated antigen
Categories	Primary Antibodies
Cellular Localization	Cytoplasmic
Chromosome Location	12q13.2
Clonality	Monoclonal
Description	This MAb recognizes protein of 26kDa-60kDa, which is identified as CD63. Its epitope is different from that of MAb LAMP3/529. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. CD63 deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression.
Host	Mouse
Immunogen	Recombinant human full-length CD63 protein
Positive Control	SK-MEL-28, HL60, THP-1 or NIH/3T3 cells. Melanoma or lymphoma.
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	P08962
Uniprot	445570
Gene Id	967

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, IHC-F

Description

(Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F

Dilution

FACS	0.5-1μg/million cells in 0.1ml
IF	0.5-1μg/ml
IHC-F	1-2μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10206787	967-MSM5-P1ABX	100µg	$393.20		Add to Cart

Anti-CD63 Antibody BHA10206787

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