Anti-CD34 Antibody BHA10206539

Mfr.No.	947-MSM2-P1BX
Alternative Names	Hematopoietic Progenitor Cell Antigen, HPCA1, Mucosialin
Categories	Primary Antibodies
Cellular Localization	Cell Surface
Chromosome Location	1q32.2
Clonality	Monoclonal
Description	This MAb recognizes a single chain, transmembrane, heavily glycosylated protein of 90-120kDa, which is identified as CD34. On the basis of differential sensitivity to degradation by specific enzymes, epitopes of monoclonal antibodies to CD34 are classified intoĀthree main categories, class I, class II and class III. It is a class II antibody whose epitope is resistant to neuraminidase but sensitive to glycoprotease and chymopapain.ĀCD34 expression is a hallmark for identifying pluripotent hematopoietic stem or progenitor cells. Its expression is gradually lost as lineage committed progenitors differentiate. CD34 is a marker of choice for staining blasts in acute myeloid leukemia. In addition, CD34 is expressed by soft tissue tumors, such as solitary fibrous tumor and gastrointestinal stromal tumor. Its expression is also found in vascular endothelium. Additionally, it appears that proliferating endothelial cells express this molecule more than the non-proliferating endothelial cells. Anti-CD34 labels > 85% of angiosarcoma and Kaposi s sarcoma, but with a lower specificity.
Host	Mouse
Immunogen	Detergent solubilized vesicular suspension prepared from human term placenta
Positive Control	KG-1 cells, Tonsil, or Angiosarcoma
Reactivity	Human, Cynomolgus Monkey, Rhesus monkey
Recombinant	FALSE
Regulatory	RUO

Swissprot	P28906
Uniprot	374990
Gene Id	947

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA at 1.0mg/ml

Applications

FACS, IF, IHC-F

Description

(Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F

Dilution

FACS	0.5-1μg/million cells in 0.1ml
IF	0.5-1μg/ml
IHC-F	0.25-0.5μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10206539	947-MSM2-P1BX	100µg	$393.20		Add to Cart

Anti-CD34 Antibody BHA10206539

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