It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi.ĀRecent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.
Host
Mouse
Immunogen
SK-MEL-23 cells (TA99); Recombinant full-length human TYRP1 protein (TYRP1/807)
Positive Control
SK-MEL-23, SK-MEL-19, SK-MEL-30, SK-MEL-37 cells or Melanoma.
Reactivity
Human, Mouse
Recombinant
FALSE
Regulatory
RUO
Swissprot
P17643
Uniprot
270279
Gene Id
7306
Buffer
200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide. Also available WITHOUT BSA; azide at 1.0mg/ml.
Concentration
1.0mg/ml
Description
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Applications
FACS, IF, WB, IHC(fro)
Description
Optimal dilution for a specific application should be determined., FACS ; IF ; WB ; IHC(fro)
Dilution
FACS
0.5-1μg/million cells in 0.1ml
IF
1-2μg/ml
WB
0.5-1μg/ml
IHC(fro)
0.5-1μg/ml for 30 minutes at RT
Reviews of Anti-Tyrosinase-Related Protein-1 (TYRP-1) Antibody BHA10205634