Anti-Fascin-1 Antibody BHA10204981

Mfr.No.	6624-MSM1-P1ABX
Alternative Names	55kDa actin-bundling protein ; FAN1 ; Fascin homolog 1 ; Fascin1 ; FSCN1 ; HSN ; p55 ; Singed (Drosophila) like (sea urchin fascin homolog like) ; SNL
Categories	Primary Antibodies
Cellular Localization	Cytoplasmic
Chromosome Location	7p22.1
Clonality	Monoclonal
Description	Recognizes a protein of 55kDa, which is identified as fascin-1. Its actin binding ability is regulated by phosphorylation. Antibody to fascin-1 is a very sensitive marker for Reed-Sternberg cells and variants in nodular sclerosis, mixed cellularity, and lymphocyte depletion Hodgkinā€™s disease. It is uniformly negative in lymphoid cells, plasma cells, and myeloid cells. Fascin-1 is also expressed in dendritic cells. This marker may be helpful to distinguish between Hodgkin lymphoma and non-Hodgkin lymphoma in difficult cases. Also, the lack of expression of fascin-1 in the neoplastic follicles in follicular lymphoma may be helpful in distinguishing these lymphomas from reactive follicular hyperplasia in which the number of follicular dendritic cells is normal or increased. Antibody to fascin-1 has been suggested as a prognostic marker in neuroendocrine neoplasms of the lung as well as in ovarian cancer. Fascin-1 expression may be induced by Epstein-Barr virus (EBV) infection of B cells with the possibility that viral induction of fascin in lymphoid or other cell types must also be considered in EBV-positive cases.
Host	Mouse
Immunogen	Full length recombinant human FSCN1 protein
Isotype	IgG2a Kappa
Positive Control	HeLa, MCF-7, PC-3 or BEWO cells. Hodgkin’s lymphoma, Ovarian or Testicular Carcinoma.
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	Q16658
Uniprot	118400
Gene Id	6624

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 1mM EDTA, pH 8.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F

Dilution

FACS	0.5-1μg/million cells in 0.1ml
IF	1-2μg/ml
IHC-F	0.5-1.0μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10204981	6624-MSM1-P1ABX	100µg	$393.20		Add to Cart

Anti-Fascin-1 Antibody BHA10204981

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