Anti-TTF-1 / NKX2.1 Antibody BHA10205345

Mfr.No.	7080-MSM2-P1ABX
Alternative Names	BCH ; Benign chorea ; BHC ; Homeobox protein Nkx2.1 ; NK2 homeobox 1 ; NKX2.1 ; NKX2A ; TEBP ; Thyroid nuclear factor-1 ; Thyroid specific enhancer binding protein
Categories	Primary Antibodies
Cellular Localization	Nuclear
Chromosome Location	14q13.3
Clonality	Monoclonal
Description	Recognizes a protein of 40kDa, identified as Thyroid transcription factor-1 (TTF-1). TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates.ĀLoss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies.
Host	Mouse
Immunogen	Recombinant TTF-1 protein
Isotype	IgG1 Kappa
Positive Control	MAD109, MLE-15, H441-4, or H345 cells. Normal thyroid or lung.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO

Swissprot	P43699
Uniprot	94367
Gene Id	7080

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F

Dilution