Anti-Rb1 (Tumor Suppressor Protein) Antibody BHA10204635

Mfr.No.	5925-MSM1-P1ABX
Alternative Names	OSRC ; Osteosarcoma ; p105-Rb ; PP105 ; pp110 ; pRb ; Prepro retinoblastoma associated protein ; RB1 ; Retinoblastoma 1 ; Retinoblastoma-associated protein
Categories	Primary Antibodies
Cellular Localization	Nuclear
Chromosome Location	13q14.2
Clonality	monoclonal
Description	Recognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. Its epitope is localized between aa 703-772. It shows no cross reaction with p107 or p130. It specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It does not stain the Rb-negative BT549 cells. It reacts with the hyperphosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma.
Host	Mouse
Immunogen	Recombinant human Rb1 protein fragment of 283 amino acid residues (exact sequence is proprietary)
Isotype	IgG1 Kappa
Positive Control	HeLa, A431 or BT-20 cells. Breast or Colon carcinoma.
Reactivity	Human, Mouse
Recombinant	FALSE
Regulatory	RUO

Swissprot	P06400
Uniprot	408528
Gene Id	5925

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

WB, IP, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined., WB ; IP ; IHC-F

Dilution

WB	0.5-1μg/ml
IP	0.5-1 �g/500ug protein lysate
IHC-F	1-2μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10204635	5925-MSM1-P1ABX	100µg	$393.20		Add to Cart

Anti-Rb1 (Tumor Suppressor Protein) Antibody BHA10204635

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