Anti-Bcl-2 Antibody BHA10204703

Mfr.No.	596-MSM2-P1ABX
Alternative Names	Apoptosis regulator Bcl-2 ; B-cell CLL/lymphoma-2
Categories	Primary Antibodies
Cellular Localization	Outer mitochondrial membranes, endoplasmic reticulum, nuclear membranes
Chromosome Location	18q21.33
Clonality	Monoclonal
Description	This antibody recognizes a protein of 25-26kDa, identified as the bcl-2 α oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of bcl-2 α oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2 α protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative.
Host	Mouse
Immunogen	A synthetic peptide, aa41-54 (GAAPAPGIFSSQPG-Cys) of human Bcl-2 protein.
Isotype	IgG1 Kappa
Positive Control	Jurkat, K562, HL-60, or HeLa Cells. Tonsil or follicular lymphomas.
Reactivity	Human, Monkey, Pig
Recombinant	FALSE
Regulatory	RUO

Swissprot	P10415
Uniprot	150749
Gene Id	596

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, WB, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined., FACS ; IF ; WB ; IHC-F

Dilution

FACS	0.5-1μg/million cells in 0.1ml
IF	1-2μg/ml
WB	0.5-1μg/ml
IHC-F	0.5-1μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10204703	596-MSM2-P1ABX	100µg	$393.20		Add to Cart

Anti-Bcl-2 Antibody BHA10204703

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