Anti-Beta-2 Microglobulin Antibody BHA10204377

Mfr.No.	567-MSM5-P1ABX
Alternative Names	B2M ; Beta 2 microglobin ; Beta 2 microglobulin ; Beta chain of MHC class I molecules ; Beta-2-microglobulin form pI 5.3 ; Hdcma22p
Categories	Primary Antibodies
Cellular Localization	Cell Surface, Extracellular(secreted)
Chromosome Location	15q21-q22.2
Clonality	Monoclonal
Description	Recognizes a protein of 12kDa, identified as β-2 microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an α heavy chain that contains three subdomains (α1, α2, α3) and a non-covalent associating light chain, known as β-2-Microglobulin. β-2-Microglobulin associates with the α3 subdomain of the α heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The α1 and α2 domains of the α heavy chain form the peptide antigen-binding cleft. Mutations in the β-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.
Host	Mouse
Immunogen	Full length recombinant human B2M protein
Isotype	IgG2b Kappa
Positive Control	HL-60 or HeLa cells. Melanomas and Lymphoma. Carcinoma of Stomach, Cervix, Endometrial, Kidney or Colon.
Reactivity	Human, non-human primates
Recombinant	FALSE
Regulatory	RUO

Swissprot	P61769
Uniprot	534255
Gene Id	567

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F

Dilution