Anti-Parathyroid Hormone (PTH) (N- & C-Terminal) Antibody BHA10204417

Mfr.No.	5741-MSM6-P1ABX
Alternative Names	hPTH ; Parathormone ; Parathyrin ; Parathyroid hormone 1 (PTH1) ; Parathyroid hormone (PTH)
Categories	Primary Antibodies
Cellular Localization	Cytoplasmic (Secreted)
Chromosome Location	11p15.3-p15.1
Clonality	Monoclonal
Description	Epitope of this MAb maps in the C-terminus of PTH, a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.
Host	Mouse
Immunogen	Synthetic peptide corresponding to amino acids 1 to 34 of PTH conjugated to a carrier (3H9); Recombinant fragment (84 amino acid residues from C-terminus; aa32-115) of human PTH protein
Isotype	IgG2b Kappa
Positive Control	Human parathyroid gland carcinoma
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	P01270
Uniprot	37045
Gene Id	5741

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F

Dilution

FACS	0.5-1μg/million cells
IF	0.5-1μg/ml
IHC-F	0.5-1.0μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10204417	5741-MSM6-P1ABX	100µg	$393.20		Add to Cart

Anti-Parathyroid Hormone (PTH) (N- & C-Terminal) Antibody BHA10204417

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