Anti-NGF-Receptor (p75) / CD271 Antibody BHA10203824

Mfr.No.	4804-MSM2-P0
Alternative Names	CD271 ; Gp80-LNGFR ; Low affinity nerve growth factor receptor ; Low affinity neurotrophin receptor p75NTR ; Nerve growth factor receptor (NGFR) ; p75 ICD ; p75 Neurotrophin receptor ; Tumor necrosis factor receptor superfamily member 16 (TNFRSF16)
Categories	Primary Antibodies
Cellular Localization	Cell Surface, Cytoplasmic
Chromosome Location	17q21-22
Clonality	Monoclonal
Description	It recognizes a glycoprotein of 75kDa, identified as low affinity Nerve Growth Factor (NGF) Receptor (p75NGFR) or Neurotrophin Receptor (p75NTR). NGFR is expressed in various neural crest cells and their tumors such as melanocytes, melanomas, neuroblastomas, pheochromocytomas and neurofibromas. Reportedly, anti-NGFR is a reliable marker for desmoplastic and neurotropic melanomas. NGFR is expressed in mature non-neural cells such as perivascular cells, dental pulp cells, lymphoidal follicular dendritic cells, basal epithelium of oral mucosa and hair follicles, prostate basal cells, and myoepithelial cells. Anti-NGFR stains the myoepithelial cells of breast ducts and intra-lobular fibroblasts of breast ducts.
Host	Mouse
Immunogen	Recombinant human p75 NGFR protein
Isotype	IgG1 Kappa
Positive Control	Neuronal axons, Schwann cells, and perineural cells of peripheral nerves, or tumors of nerve sheath differentiation e.g. Schwannoma, Neurofibroma. Soma and axons of sensory neurons, and ganglionic satellite cells. Melanomas.
Reactivity	Human, non-human primates
Recombinant	FALSE
Regulatory	RUO

Swissprot	P08138
Uniprot	415768; 681726
Gene Id	4804

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	200µg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab with BSA and Azide at 200μg/ml

Applications

FACS, IF, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F

Dilution