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Home / Primary Antibodies / Flow Cytometry (FACS)

Anti-MUC5AC (Mucin 5AC / Gastric Mucin) Antibody BHA10203543

SKU : BHA10203543

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NeoBiotechnologies, Inc.

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Mfr.No.	4586-MSM7-P1ABX
Alternative Names	Apomucin Major Airway Glycoprotein ; Mucin 5 subtype AC tracheobronchial ; Mucin 5 Subtypes A And C ; Mucin 5AC oligomeric mucus/gel forming ; Tracheobronchial Mucin (TBM)
Categories	Primary Antibodies
Cellular Localization	Cytoplasmic
Chromosome Location	11p15.5
Clonality	Monoclonal
Description	This MAb recognizes the peptide core of gastric mucin M1 (recently identified as Mucin 5AC).ĀIts epitope is located in the N-terminal cysteine rich part of the peptide core of MUC5AC, which is heavily glycosylated. Its epitope is destroyed by beta-mercaptoethanol but not by periodate treatment. MAb 2-11M1 reacts with the protein backbone exclusively; it only reacts with fully deglycosylated MUC5AC. Therefore, the material under test should also be fully deglycosylated. This can be achieved with standard periodate oxidation method. The success of the deglycosylation can be checked with routine PAS (Periodic Acid Shiff) staining. After deglycosylation, the preparation should no longer be stainable with PAS reagent. Only then 2-11M1 will react should MUC5AC be present. This mucin is present in primary ovarian mucinous cancer but usually absent in colorectal adenocarcinoma, thus showing an expression pattern opposite to MUC2. Together with a panel of antibodies, Anti-MUC5AC may be useful for differential identification of primary mucinous ovarian tumors from colon adenocarcinoma metastatic to the ovary. MUC5AC antibodies may also be useful for identification of intestinal metaplasia as well as in the identification of pancreatic carcinoma and pre-cancerous changes vs. normal pancreas.
Host	Mouse
Immunogen	M1 mucin preparation from the fluid of an ovarian mucinous cyst belonging to an O Le(a-b) patient
Isotype	IgG1 Kappa
Positive Control	MCF-7 cells or Stomach
Reactivity	Human, Monkey, Cow, Cat, Mouse
Recombinant	FALSE
Regulatory	RUO

Swissprot	P98088
Uniprot	534332
Gene Id	4586

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide. Also available WITHOUT BSA; azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, IHC-F

Description

Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F

Dilution

FACS	0.5-1μg/million cells in 0.1ml
IF	1-2μg/ml
IHC-F	0.5-1μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10203543	4586-MSM7-P1ABX	100µg	$393.20		Add to Cart

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