Anti-CD61 / Integrin beta-3 / Platelet Glycoprotein IIIa Antibody BHA10202517

Mfr.No.	3690-MSM3-P1ABX
Alternative Names	BDPLT2 ; GP3A ; GPIIIa ; GT ; HPA 1 ; HPA 4 ; Integrin beta-3 ; ITGB3 ; NAIT ; Platelet fibrinogen receptor beta subunit
Categories	Primary Antibodies
Cellular Localization	Cell Surface
Chromosome Location	17q21.32
Clonality	Monoclonal
Description	Reacts with human integrin beta3 (GPIIIa, vitronectin receptor beta chain). It associates with the αV-chain (CD51) to form vitronectin receptor, or with the αIIb-chain (CD41) to form the GpIIb/GpIIIa complex (CD41/CD61). The CD41/CD61 complex appears early in megakaryocyte maturation. The activated CD41/CD61 complex is a receptor for von Willebrand factor, soluble fibrinogen, fibronectin, vitronectin and thrombospondin. It plays a central role in platelet activation and aggregation. The CD51/CD61 is implicated in tumor metastasis and adenoviral infection. The antibody detects platelets in smears of blood and bone marrow, as well as megakaryocytes in frozen sections and cell smears. The antibody is useful for classification of megakaryoblastic leukemia.
Host	Mouse
Immunogen	Recombinant human ITGB3 protein
Isotype	IgG1 Kappa
Positive Control	U937, KG1a, HEL cells. Spleen
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	P05106
Uniprot	218040
Gene Id	3690

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, IHC-Ff

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes) ,Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-Ff

Dilution

FACS	0.5-1μg/million cells in 0.1ml
IF	0.5-1μg/ml
IHC-Ff	1-2μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10202517	3690-MSM3-P1ABX	100µg	$393.20		Add to Cart

Anti-CD61 / Integrin beta-3 / Platelet Glycoprotein IIIa Antibody BHA10202517

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