Anti-CD11c Antibody BHA10202492

Mfr.No.	3687-MSM3-P1ABX
Alternative Names	CD11 antigen-like family member C ; Complement component 3 receptor 4 subunit ; Integrin alpha-X ; integrin, alpha X (antigen CD11C (p150), alpha polypeptide) ; Leu M5 alpha subunit ; Leukocyte adhesion glycoprotein p150 95 alpha chain ; Myeloid membrane antigen alpha subunit ; p150/95
Categories	Primary Antibodies
Cellular Localization	Cell Surface
Clonality	Monoclonal
Description	Recognizes a protein of 145kDa, identified as CD11c. CD11c (ITGAX), a member of the leukointegrin family, shares the same beta subunit with other members of the leukocyte adhesion molecule family, which includes CD11a (LFA-1), CD11b (MAC-1) and CD11d (ITGAD), but has a unique alpha chain. CD11c has been shown to play a role in phagocytosis, cell migration, and cytokine production by monocytes/macrophages as well as induction of T-cell proliferation by Langerhans cells. CD11c is expressed prominently on the plasma membranes of monocytes, tissue macrophages, NK cells, and most dendritic cells (DCs). A lower level of expression is also observed on neutrophils as a result of its high level of expression on most DCs. An antibody to CD11c may aid in identification of lesions with histiocytic origin. It may also been used as a marker for hairy cell leukemia in paraffin-embedded tissues.
Host	Mouse
Immunogen	Recombinant human ITGAX protein fragment (aa 637-827) (exact sequence is proprietary)
Isotype	IgG2b Kappa
Positive Control	Human dendritic cells. Human lymph nodes and tonsils.
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	P20702 (Human)
Uniprot	248472 (Human)Human Gene SymbolITGAXHu Chromosome Location16p11.2
Gene Id	3687 (Human)

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes) Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F

Dilution

FACS	0.5-1μg/million cells
IF	0.5-1μg/ml
IHC-F	1-2μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10202492	3687-MSM3-P1ABX	100µg	$393.20		Add to Cart

Anti-CD11c Antibody BHA10202492

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