Anti-HLA-DRB (MHC II) Antibody BHA10201888

Mfr.No.	3123-MSM2-P1ABX
Alternative Names	DRB1 ; HLA class II histocompatibility antigen, DR-1 beta chain ; HLA-DR-beta 1 ; HLA-DRB1 ; human leucocyte antigen DRB1 ; Leucocyte antigen DR beta 1 chain ; lymphocyte antigen DRB1 ; major histocompatibility complex, class II, DR beta 1 ; MHC class II HLA-DR beta 1 chain ; MHC class II HLA-DR-beta cell surface glycoprotein
Categories	Primary Antibodies
Cellular Localization	Cell Surface
Chromosome Location	6p21.3
Clonality	Monoclonal
Description	This MAb reacts with the beta-chain of HLA-DRB1 antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. Its epitope is different from that of MAb L243. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kDa alpha (heavy) chain and a 28kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense cytoplasmic staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma.
Host	Mouse
Immunogen	Activated human peripheral blood mononuclear cells
Isotype	IgG2b Kappa
Positive Control	Ramos, Daudi or HuT78 cells. Tonsil or lymph node
Reactivity	Human, Monkey
Recombinant	FALSE
Regulatory	RUO

Swissprot	P01911
Uniprot	534322
Gene Id	3123

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, WB, IHC-F

Description

(Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined., FACS ; IF ; WB ; IHC-F

Dilution

FACS	0.5-1μg/million cells in 0.1ml
IF	0.5-1μg/ml
WB	0.5-1μg/ml
IHC-F	0.25-0.5μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10201888	3123-MSM2-P1ABX	100µg	$393.20		Add to Cart

Anti-HLA-DRB (MHC II) Antibody BHA10201888

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