Recognizes a protein of 102kDa, identified as Catenin, alpha-1. Catenins comprise a large family of Ca2+-dependent, homotypic cell-cell adhesion molecules that play important roles in development, epithelial cell polarity and tumor progression. Alpha-catenin is a key regulator of actin dynamics in cell-cell adhesion. During cell-cell adhesion, α-catenin forms a heterodimer with β-catenin and links the cadherins to actin associated with the cytoskeleton. Alpha-catenin also regulates the beta-catenin signaling in various cells. It displays the tumor suppressor activity and is found to be down regulated in some forms of breast cancer.
Host
Mouse
Immunogen
Human alpha catenin fusion protein
Isotype
IgG1
Positive Control
HeLa, A431 or MCF-7 Cells.
Reactivity
Human
Recombinant
FALSE
Regulatory
RUO
Swissprot
P35221
Uniprot
445981
Gene Id
1495
Buffer
200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide. Also available WITHOUT BSA; azide at 1.0mg/ml.
Concentration
1.0mg/ml
Description
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Applications
FACS, IF, WB, IHC(fro)
Description
Optimal dilution for a specific application should be determined., FACS ; IF ; WB ; IHC(fro)
Dilution
FACS
0.5-1μg/million cells
IF
1-2μg/ml
WB
0.5-1.0μg/ml
IHC(fro)
Reviews of Anti-Catenin, alpha-1 (CTNNA1) Antibody BHA10200633