Anti-N-Cadherin / Cadherin-2 / CD325 (NCAD) Antibody BHA10200013

Mfr.No.	1000-MSM3-P1ABX
Alternative Names	Cadherin-2 N cadherin neuronal ; Cadherin-2 type 1 ; Cadherin-2 ; Calcium dependent adhesion protein neuronal ; CD325 ; CDH2 ; CDHN ; CDw325 ; N-Cadherin ; NCAD
Categories	Primary Antibodies
Cellular Localization	Cell Surface
Chromosome Location	18q11.2
Clonality	Monoclonal
Description	Recognizes a protein of ~140kDa, identified as N-Cadherin (NCAD), also known as CD325. N-cadherin is a 140 kDa protein belonging to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. Expression of N-cadherin has been reported on a variety of normal tissues including neuronal, endothelial and muscle cells, and a subpopulation of early hematopoietic progenitor cells. Results aid in the classification of malignant non-carcinomatous neoplasms including mesotheliomas, chordomas, synovial sarcomas, malignant melanomas, epithelioid sarcomas, epithelioid angiosarcomas, clear cell sarcomas as well as serous and endometrioid tumors of the ovary have been demonstrated to be N-cadherin positive, whereas mucinous tumors are negative. Other N-cadherin-positive neoplasms include renal cell carcinomas and some variant breast tumors, including medullary breast carcinomas and sarcomatoid metaplastic breast carcinomas.
Host	Mouse
Immunogen	Recombinant human CDH2 intracellular domain (exact sequence is proprietary)
Isotype	IgG1 Kappa
Positive Control	HeLa or HUVEC cells. Heart, Pancreas or Cerebral Cortex
Reactivity	Human, Mouse
Recombinant	FALSE
Regulatory	RUO

Swissprot	P19022
Uniprot	464829
Gene Id	1000

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, WB, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tis with1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined., FACS ; WB ; IHC-F

Dilution

FACS	0.5-1μg/million cells
WB	0.5-1.0μg/ml
IHC-F	0.5-1.0μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10200013	1000-MSM3-P1ABX	100µg	$393.20		Add to Cart

Anti-N-Cadherin / Cadherin-2 / CD325 (NCAD) Antibody BHA10200013

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