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Home / Biochemicals / Small Molecules

ICA-27243

SKU : BHB21300172

A Potent and Selective Opener of KCNQ2 and KCNQ3 K+ Channels

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Mfr.No.	I-130, I-130_10 mg, I-130_25 mg, I-130_5 mg, I-130_50 mg
Description	ICA-27243 (#I-130) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C₁₂H₇ClF₂N₂O.
Background	KCNQ2 (KV7.2) and KCNQ3 (KV7.3) are voltage-gated K+ channel subunits that underlie the neuronal M current. ICA-27243 is a novel, potent and selective activator of M-current and KCNQ2/Q3 channels. ICA-27243 is structurally distinct from other known KCNQ/M-current activators. It enhances KCNQ channel activation by shifting channel opening to more hyperpolarized potentials. ICA-27243 activates KCNQ currents in Chinese hamster ovary cells expressing recombinant KCNQ2/Q3 heteromultimeric channels with an EC50 of 0.4 uM. ICA-27243 exhibits selectivity for KCNQ2/Q3 over KCNQ4 (20-fold) and KCNQ3/Q5 (>100-fold) and has no effect on GABA-activated chloride channels, neuronal Na+ channels, or voltage-gated Ca2+ channels. In addition, it produces minimal displacement of radioligand binding to a range of central nervous system receptors and transporters. ICA-27243 also suppresses seizure-like activity in an ex vivo hippocampal slice model, and protects against maximal electroshock-induced seizures in mice1.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.5-50 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. Soluble in water. Once dissolved in water, add an equal volume of glycerol. Do not shake or vortex. Avoid multiple freeze-thawing cycles
Cas Number	325457-89-4
Molecular Weight	268.64
Solubility	100 mM DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	KCNQ2, KCNQ3 K⁺ channels
Source	Synthetic
Activity	ICA-27243 is a potent and selective KCNQ channel modulator (enhancer)1 with EC50 ~ 1 uM.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: N-(6-Chloro-pyridin-3-yl)-3,4-difluoro-benzamide.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Wickenden, A.D. et al. (2008) Mol. Pharmacol. 73, 977. Padilla, K. et al. (2009) Neurosci. Lett. 465, 138.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300172-1	I-130_10 mg	10 mg	$306		Add to Cart
BHB21300172-2	I-130_25 mg	25 mg	$609		Add to Cart
BHB21300172-3	I-130_5 mg	5 mg	$193		Add to Cart
BHB21300172-4	I-130_50 mg	50 mg	$1094		Add to Cart

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