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Home / Proteins & Peptide

Human Recombinant Transthyretin (TTR) L55P Variant Filaments

SKU : BHP11901177

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StressMarq Biosciences Inc.

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Mfr.No.	SPR-464, SPR-464B, SPR-464C, SPR-464E
Alternative Names	Amyloid polyneuropathy Protein, Amyloidosis I Protein, ATTR Protein, Carpal tunnel syndrome 1 Protein, CTS Protein, CTS1 Protein, HEL111 Protein, HsT2651 Protein, PALB Protein, Prealbumin Protein, Prealbumin amyloidosis type I Protein, Prealbumin Thyroxine-binding Protein, TBPA Protein, Thyroxine binding prealbumin Protein, Transthyretin Protein, TTHY_HUMAN Protein,TTR Protein
Cellular Localization	Extracellular exosome, Cytoplasm, Extracellular Region, Lysosome
Certificate Of Analysis	Certified >95% pure using SDS-PAGE analysis.
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.
Scientific Background	Transthyretin is a transport protein in the serum and cerebospinal fluid that carried the thyroid hormone Thyroxine and retinol-binding protein bound to retinol. TTR misfolding and aggregation is known to be associated with the amyloiddiseases SSA, FAP and FAC (1-5). TTR is also thought to have beneficial side effects, such as binding to beta-amyloid protein, preventing beta-amyloid from accumulating into the plaques associated with Alzheimer's Disease (6). The L55P variant TTR is distinct from the other variants in that the L55P tetramer can dissociate to the monomeric amyloidogenic intermediate and form fibril precursors (7).
Species	Human
Specificity	15.887 kDa
Accession Number	NP_000362.1
Concentration	Lot/batch specific. See included datasheet.
Purification	Ion-exchange Purified
Expression System	E. coli
Biological Activity Abreviation	Under Investigation
Cite This Product	Human Recombinant TTR Protein (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SPR-464B)
Nature	Recombinant
Other Relevant Information	For best results, sonicate immediately prior to use. Refer to the Neurodegenerative Protein Handling Instructions on our website, or on the product datasheet for further information..
Protein Length	Full length

Gross Weight (kg)	1.4
Launch Date	2019/03/18
Net Weight (g)	0.1
Swissprot	P02766
Target Details	Transthyretin (TTR)
Gene Id	7276
Research Area	Tangles & Tau, Lipid and lipoprotein Metabolism, Neurodegeneration, Alzheimer's Disease, ALS Disease, Parkinson's Disease, Cardiovascular System, Blood, Cell Signaling, Metabolism, Neuroscience
Antigen	Transthyretin

Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.19.0030
Un Code For Transport	Non-hazardous
Unspsc Code	12352202
Shipping Temperature	Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.
Buffer	PBS pH 7.4
Purity	>95%
Storage	-80 °C
Storage Buffer	PBS pH 7.4
Storage Temperature	-80°C

Applications	In vivo assay, In vitro assay, WB, SDS-PAGE

Reference	1. Zeldenrust S.R., Benson M.D. (2010). Wiley. pp. 795815. 2. Westermark P., Sletten K., Johansson B., Cornwell G.G. (1990). Proc. Natl. Acad. Sci. U.S.A. 87(7): 28435. 3. Andrade C. (1952). Brain. 75(3): 40827. 4. Coelho T. (1996). Curr. Opin. Neurol. 9(5): 3559. 5. Jacobson D.R, et. al. (1997). N. Engl. J. Med. 336(7): 46673. 6. Li X. (2011). Mol Neurodegener. 6(1):79. 7. Lashuel H.A., Wurth C., Woo L., and Kelly J.W. (1999) Biochem. 38(41): 13560-13573.

Product Manual	Datasheet
SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP11901177-1	SPR-464B	100 ug	$440		Add to Cart
BHP11901177-2	SPR-464C	100 ug x2	$790		Add to Cart
BHP11901177-3	SPR-464E	100 ug x5	$1640		Add to Cart

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