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Human Recombinant HSP90 alpha Protein

SKU : BHP11900001

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StressMarq Biosciences Inc.

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Mfr.No.	SPR-101, SPR-101A, SPR-101B
Description	Human Recombinant HSP90 alpha Protein
Alternative Names	HSP86 Protein, HSP89A Protein, HSP90A Protein, HSP90AA1 Protein, HSPC1 Protein, HSPCA Protein, HSPCAL3 Protein, HSP90alpha Protein
Cellular Localization	Cytoplasm, Melanosome
Certificate Of Analysis	This product has been certified >90% pure using SDSPAGE analysis.
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.
Regulatory	RUO
Scientific Background	HSP90 is a highly conserved and essential stress protein that is expressed in all eukaryotic cells. From a functional perspective, HSP90 participates in the folding, assembly, maturation, and stabilization of specific proteins as an integral component of a chaperone complex (1-4). Despite its label of being a heat-shock protein, HSP90 is one of the most highly expressed proteins in unstressed cells (12% of cytosolic protein). It carries out a number of housekeeping functions including controlling the activity, turnover, and trafficking of a variety of proteins. Most of the HSP90-regulated proteins that have been discovered to date are involved in cell signaling (5-6). The number of proteins now know to interact with HSP90 is about 100. Target proteins include the kinases v-Src, Wee1, and c-Raf, transcriptional regulators such as p53 and steroid receptors, and the polymerases of the hepatitis B virus and telomerase.5. When bound to ATP, HSP90 interacts with co-chaperones Cdc37, p23, and an assortment of immunophilin-like proteins, forming a complex that stabilizes and protects target proteins from proteasomal degradation. In most cases, HSP90-interacting proteins have been shown to co-precipitate with HSP90 when carrying out immunoadsorption studies, and to exist in cytosolic heterocomplexes with it. In a number of cases, variations in HSP90 expression or HSP90 mutation has been shown to degrade signaling function via the protein or to impair a specific function of the protein (such as steroid binding, kinase activity) in vivo. Ansamycin antibiotics, such as geldanamycin and radicicol, inhibit HSP90 function (7). Looking for more information on HSP90 Visit our new HSP90 Scientific Resource Guide at http://www.HSP90.ca.
Species	Human
Specificity	~90 kDa
Accession Number	NP_001017963.2
Concentration	Lot/batch specific. See included datasheet.
Purification	Affinity Purified
Expression System	E. coli
Cite This Product	Human Recombinant HSP90 alpha Protein (StressMarq Biosciences, Canada, Cat # SPR-101A)
Mol Weight	~90 kDa
Nature	Recombinant
Protein Length	Full Length

Gross Weight (kg)	1.4
Launch Date	2007/12/01
Net Weight (g)	0.05
Number Of Pubmed Citations	8
Swissprot	P07900, P07900
Target Details	HSP90 alpha
Gene Id	3320
Research Area	Cancer, Heat Shock, Cell Signaling, Chaperone Proteins, Tumor Biomarkers, Protein Trafficking
Antigen	HSP90 Alpha
Target	HSP90 alpha

Adr Code	Non-hazardous
Country Of Origin	Canada
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Published Application	Functional Assay ; DARTs Assay ; Functional Assay ; ATPase activity assay ; Surface Plasmon Resonance Spectroscopy ; ATPase activity assay ; ATPase activity assay ; Western Blot Control
Published Species Reactivity	Human ; Mouse
Pubmed Id	28558721 ; 28495207 ; 27470541 ; 27194788 ; 26840910 ; 22497853 ; 21553813 ; 21084432
Shipping	Blue Ice or 4ºC
Stock Product	Y
Tarriff Code	3822.19.0030
Un Code For Transport	Non-hazardous
Unspsc Code	12352202
Shipping Temperature	Blue Ice or 4°C
Buffer	50mM Tris/HCl pH7.5, 5mM Bme, 0.3M NaCl, 10% glycerol
Description	Accession Number: AJ890083 Specificity: ~90 kDa Certificate of Analysis: This product has been certified >90% pure using SDSPAGE analysis. Country of Origin: Canada Gross Weight (kg): 1.4 Net Weight (g): 0.05 Stock Product: Y
Purity	>90%
Storage Buffer	50mM Tris/HCl pH7.5, 5mM Bme, 0.3M NaCl, 10% glycerol
Storage Temperature	-20°C

Immunogen Species	Homo Sapiens (Human)
Applications	ATPase Activity assay, Surface Plasmon Resonance, DARTs assay, WB, SDS-PAGE, SB

Reference	1. Arlander S.J.H., et al. (2003) J Biol Chem. 278: 52572-52577. 2. Pearl H., et al. (2001) Adv Protein Chem. 59:157-186. 3. Neckers L., et al. (2002) Trends Mol Med. 8:S55-S61. 4. Pratt W., Toft D. (2003) Exp Biol Med. 228:111-133. 5. Pratt W., Toft D. (1997) Endocr Rev. 18: 306360. 6. Pratt W.B. (1998) Proc Soc Exptl Biol Med. 217: 420434. 7. Whitesell L., et al. (1994) Proc Natl Acad Sci USA. 91: 8324 8328.

Product Manual	Datasheet
SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP11900001-1	SPR-101A	50 ug	$141		Add to Cart
BHP11900001-2	SPR-101B	100 ug	$235		Add to Cart

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