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Home / Proteins & Peptide

Human Recombinant Alpha Synuclein Oligomers (Dopamine HCL Stabilized)

SKU : BHP11901183

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StressMarq Biosciences Inc.

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Mfr.No.	SPR-466, SPR-466B, SPR-466C, SPR-466E
Alternative Names	Alpha synuclein protein, Alpha-synuclein oligomer, Alpha synuclein protein oligomer, Alpha-synuclein protein, Non-A beta component of AD amyloid protein, Non-A4 component of amyloid precursor protein, NACP protein, SNCA protein, NACP protein, PARK1 protein, Alpha synuclein oligomers, Alpha Synuclein Protein Oligomers, SYN protein, Parkinson's disease familial 1 Protein
Cellular Localization	Cytoplasm, Membrane, Nucleus
Certificate Of Analysis	Certified >95% pure using SDS-PAGE analysis.
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.
Scientific Background	Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6). Dopamine inhibits alpha synuclein fibrillogenesis leading to oligomer accumulation in vitro (7), (8) and in vivo (9), (10).
Species	Human
Specificity	~14.46kDa
Accession Number	NP_000336.1
Concentration	Lot/batch specific. See included datasheet.
Purification	Ion-exchange Purified. Monomeric alpha synuclein was removed via filtration.
Expression System	E. coli
Biological Activity Abreviation	Under Investigation
Cite This Product	Human Recombinant Alpha Synuclein Protein (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SPR-466B)
Nature	Recombinant
Protein Length	Full length

Gross Weight (kg)	1.4
Launch Date	2019/03/18
Net Weight (g)	0.1
Swissprot	P37840
Target Details	Alpha Synuclein Oligomers
Gene Id	6622
Research Area	Tangles & Tau, Multiple System Atrophy, Neurodegeneration, Alzheimer's Disease, Parkinson's Disease, Synuclein, Neuroscience
Antigen	Alpha Synuclein

Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.19.0030
Un Code For Transport	Non-hazardous
Unspsc Code	12352202
Shipping Temperature	Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.
Buffer	PBS pH 7.4
Purity	>95%
Storage	-80 °C
Storage Buffer	PBS pH 7.4
Storage Temperature	-80°C

Applications	In vivo assay, In vitro assay, WB, SDS-PAGE

Reference	1. Genetics Home Reference: SNCA. US National Library of Medicine. (2013). 2. Zhang L., et al. (2008) Brain Res. 1244: 40-52. 3. Alim M.A., et al. (2002) J Biol Chem. 277(3): 2112-2117. 4. Kokhan V.S., Afanasyeva M.A., Van'kin G. (2012) Behav. Brain. Res. 231(1): 226-230. 5. Spillantini M.G., et al. (1997) Nature. 388(6645): 839-840. 6. Mezey E., et al. (1998) Nat Med. 4(7): 755-757. 7. Conway, K.A. et al. (2001) Science 294:1346-1349. 8. Norris, E.H. et al. (2005) J Biol Chem. 280:21212-21219. 9. Mazulli, J.R. et al. (2006). J Neurosci. 26:10068-10078. 10. Mazulli, J.R. et al. (2007). J Biol Chem. 282:31621-31630.

Product Manual	Datasheet
SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP11901183-1	SPR-466B	100 ug	$620		Add to Cart
BHP11901183-2	SPR-466C	100 ug x2	$1110		Add to Cart
BHP11901183-3	SPR-466E	100 ug x5	$2155		Add to Cart

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