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Home / Biochemicals / Small Molecules

GW 791343 hydrochloride

SKU : BHB21300147

A Negative Allosteric Modulator of Human P2X7 Receptors

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Mfr.No.	G-115, G-115_10 mg, G-115_25 mg, G-115_5 mg, G-115_50 mg
Description	GW 791343 hydrochloride (#G-115) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C₂₀H₂₇Cl₃F₂N₄O ( C₂₀H₂₄F₂N₄O ÃÂ· 3HCl ).
Synonyms	Synthetic
Background	GW 791343 hydrochloride is a species-specific allosteric modulator of purinergic P2X7 receptor. The compound acts as a negative modulator of human P2X7 receptors and as a positive modulator of rat P2X71. GW 791343 displays pIC50 values between 6.9 - 7.2 on human P2X7 receptors1,2.P2X receptors are a family of ligand-gated cation channels activated by extracellular ATP, a ligand that mediates numerous cellular and biological functions. Seven members of P2X receptors are identified and shown to function either in homomeric or heteromeric combinations. The P2X receptors are widely localized in cell types of almost every origin, including neuronal, muscular, epithelial and immune and play a pivotal role in models of various pain conditions. P2X7 receptors are responsible for mediating the release of proinflammatory cytokines in inflammatory/immune conditions and pain1,3,4.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.1-10 uM.
Reconstitution	Soluble up to 100 mM in DMSO and in water. Centrifuge all products before handling (10000 x g 5 min).
Cas Number	309712-55-8
Molecular Weight	483.81
Solubility	Soluble up to 100 mM in DMSO and in water. Centrifuge all products before handling (10000 x g 5 min).
Target	P2X7 receptors
Activity	GW 791343 hydrochloride is a species-specific allosteric modulator of the purinergic P2X7 receptors, acting as a negative modulator of human P2X7 (pIC50 = 6.9 - 7.2), and as a positive modulator of rat P2X71,2.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 2-(3,4-difluoroanilino)-N-(2-methyl-5-(piperazin-1-ylmethyl)phenyl)acetamide trihydrochloride.

Purity	>99%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: -20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

Product Manual	SDS

Reference	Michel, A.D. et al. (2008) Br. J. Pharmacol. 153, 737. Michel, A.D. et al. (2008) Br. J. Pharmacol. 155, 738. Bhattacharya, A. et al. (2013) Br. J. Pharmacol. 170, 624 Swanson, D.M. et al. (2016) J. Med. Chem. 59, 8535. Michel, A.D. et al. (2008) Br. J. Pharmacol. 153, 737. Michel, A.D. et al. (2008) Br. J. Pharmacol. 155, 738.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300147-1	G-115_10 mg	10 mg	$85		Add to Cart
BHB21300147-2	G-115_25 mg	25 mg	$184		Add to Cart
BHB21300147-3	G-115_5 mg	5 mg	$66		Add to Cart
BHB21300147-4	G-115_50 mg	50 mg	$333		Add to Cart

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