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Home / Primary Antibodies / Monoclonal Antibodies

Granzyme B

SKU : BHA15100464

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Mfr.No.	AMB35-5M
Clonality	Monoclonal
Description	Granzyme B is a member of the granzyme family of the serine proteases found specifically in the cytotoxic granules of cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. They are synthesized, processed and released by exocytosis in lysosome-like granules containing perforin. Granzyme B has the strongest apoptotic activity of all the granzymes as a result of its caspase-like ability to cleave substrates at aspartic acid residues thereby activating procaspases directly and cleaving downstream caspase substrates. Recent studies have demonstrated that the expression of granzyme B by Immunohistochemistry in several entities of extranodal peripheral T cell lymphoma (PTCL) and NK cell lymphomas, including nasal and nasal-type NK/T cell lymphomas, hepatosplenic and non-hepatosplenic PTCL, enteropathy-type (ETCL) and non-ETCL intestinal PTCL, subcutaneous panniculitis-like PTCL (SPTCL), cutaneous CD8+ epidermotropic lymphomas as well as in nodal and cutaneous CD30+ anaplastic large cell lymphomas (ALCL). In contrast, only a few nodal PTCL-unspecified (UC) express cytotoxic phenotype while angioimmunoblastic (AILD) lymphomas do not. The expression of granzyme B may be important for the identification and classification of extranodal T- and NK-cell lymphomas since many of these tumors do not have specific morphology and phenotype.
Host	Mouse
Isotype	IgG2a
Reactivity	Human
Species	Mouse

Antigen	Granzyme B
Clone No	2C5
Research Area	Infectious diseases, Immune system

Buffer	PBS
Concentration	1-3ug/ml
Storage	2-8°C

Applications	IHC
Dilution	1:10-20

Product Manual	Datasheet SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
AMB35-5M	AMB35-5M	6 mL	$336		Add to Cart
AMB35-10M	AMB35-10M	100 tests - i6000	$628		Add to Cart
AXB35-50D	AXB35-50D	50 tests - Xmatrx	$353		Add to Cart
AXB35-YCD	AXB35-YCD	160 tests - Xmatrx	$860		Add to Cart
MUB35-UC	MUB35-UC	1ml Conc	$688		Add to Cart
MUB35-5UC	MUB35-5UC	0.5ml Conc	$481		Add to Cart

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