GFP expressing RGD fiber modified Adenovirus (Ad(RGD)-CMV-GFP)

Mfr.No.	1768
Description	Ad infection is initiated by recognition of the native Ad5 receptor, coxsackievirus-adenovirus receptor (CAR), on target cells by the carboxy-terminal portion (i.e., knob) of the fiber protein. Therefore the infection efficiency of adenovirus is very low for cells with low or no CAR receptors. Arg-Gly-Asp (RGD) motif was introduced in the surface-exposed loops of adenovirus fiber knob, this enables the adenovirus to bypass CAR and mediate cell entry via RGD binding integrins. So the RDG modified adenovirus can be used for "retargeting" cells that regular adenovirus doesn't work well. The infection effeciency of RDG modified adenovirus can be tens or hundreds of times higher than standard Ad5 in some cells, including human or mouse macrophages, T cells, synoviocytes, islet grafts, adipocytes, MEF, etc.This is a RGD modified replication-deficient adenovirus expressing eGFP under a CMV promoter.
Categories	Adenovirus, Over-Expression, Fiber-modified Ad5
Product Type	Pre-Made
Virus Type	Adenovirus
Function	Reporter/Tag
Promoter	CMV (ubiquitous)
Reporter	eGFP
Storage Buffer	DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone	Human Adenovirus Type5 (dE1/E3) with RGD-fiber modification
Shelf Life	12 Months
HS Code	3822190000
UNSPSC Code	41106621
Insert Gene	GFP
Serotype	RGD
Availability	Ready to Ship
Titer	1x10^10 PFU/ml
Reporter	eGFP
Storage	-80C
Shipping	Dry Ice

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SKU	Supplier No.	Size	Your price	Quantity
BHV21600336	1768	200 µL	$495		Add to Cart