PD1 Biotin 8G10 IgG1,k (RUO)

Mfr.No.	125251
Clonality	Monoclonal
Description	The clone 8G10, a mouse monoclonal antibody selectively binds with a 50-55 kD cell surface protein commonly known as Programmed cell death 1 (PD-1) or CD279, a member of the immunoglobulin superfamily. PD-1 expression is mostly observed in activated T cells and B cells, and also in dendritic cells. PD-1 signals via binding its two ligands, PD-L1 and PD-L2. Upon ligand binding, PD-1 signaling inhibits T-cell activation, leading to reduced proliferation, cytokine production, and T cell death. Blocking of PD-1 by its antibody restores T cells immunity against tumor and infectious agents. PD-1-blockade based immunotherapy is, therefore, highly clinically useful against various types of cancers and infectious diseases.
Host	Mouse
Immunogen Region	PD1 transfected HEK293 cells
Isotype	IgG1,k
Reactivity	Human

Product Manual	Datasheet MSDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA19900812-1	125251	100ug	$405		Add to Cart