CD32b FITC 4F5 IgG1,k (ASR)

Mfr.No.	4100012
Clonality	Monoclonal
Description	The clone 4F5, a mouse monoclonal antibody recognizes anti- Fc?RIIb, a cell surface protein also known as CD32b. Fc?RII has two major isoforms named Fc?RIIa and Fc?RIIb with high degree of homology. The clone 4F5 selectively reacts with Fc?RIIb but not with Fc?RIIa. The CD32b antigen is widely expressed on the cell surface of circulating B lymphocytes, monocytes, neutrophils, myeloid dendritic cells (DCs), platelets and at very low levels on plasmacytoid DCs. Fc?Rs (Fc?RI/CD64, Fc?RII/CD32, Fc?RIII/CD16, and Fc?RIV/CD16-2) play important roles in inflammatory cell activation, clearance, presentation of Ag, and maintenance of IgG homeostasis. Published reports claimed that 4F5 partially blocks the ligand-binding of FcRIIb and mediates an inhibitory signal by co-cross-linking FcRIIb with activating FcRs. Clone 4F5 supports study of the expression, regulation, and function of Fc?RIIb and may be useful in the area of therapeutic applications where the modulation of Fc?RIIb is required.
Host	Mouse
Immunogen Region	Recombinant human Fc?RIIb/c (CD32b) extracellular domain
Isotype	IgG1,k
Reactivity	Human

Product Manual	Datasheet MSDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA19901080-1	4100012	50 Test	$210		Add to Cart