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eFISH SYT Dual Color Break Apart PR

SKU : BHR15100133

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BioGenex Laboratories

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Mfr.No.	FP049-20X
Gene Name	SYT
Fluorophore	Orange/Green
Chromosome	18
Intended Use	The BioGenex eFISH SYT Dual Color Break Apart Probe is currently available forResearch use only. eFISH SYT Dual Color Break Apart Probe is designed to be used forthe detection of translocations involving the SYT gene at 18q11 in formalin-fixed,paraffin-embedded tissue or cells by fluorescence in situ hybridization (FISH).BioGenex eFISH SYT Dual Color Break Apart Probecomes in hybridization buffer. Theprobe contains green-labeled polynucleotides (Green: excitation at 503 nm and emissionat 528 nm, similar to FITC), which target sequences mapping in 18q11 proximal to theSYT gene, and orangelabeled polynucleotides (Orange: excitation at 547 nm and emissionat 572 nm, similar to rhodamine), which target sequences mapping in 18q11 distal to theSYT gene
Description	Fluorescence in situ hybridization (FISH) is a robust technique of cytogenetic used for thedetection of chromosomal aberrations, presence or absence of specific DNA sequence innative context. In this technique florescent probes bind to the target sequence of DNA inchromosome. High specificity and sensitivity coupled rapid and an accurate result hasproven role of FISH in both research and diagnosis of solid tumor and hematologicalmalignancies. As technique of cancer cytogenetics, FISH, can be used to identify geneticaberrations viz., deletions, amplification and translocation in tissue sections or withinindividual cells. FISH is also used for use in genetic counseling, medicine, and speciesidentification. FISH can also be used to detect and localize specific RNA targets in cells, circulating tumor cells, and tissue samples1,2,3,4,5.In FISH procedure, fixed tissue sections are pretreated to expose target DNA or mRNAsequences. An appropriately labeled probe is hybridized to the exposed target DNA ormRNA sequences in the cells. Subsequent stringent washing steps remove any probe thatis non-specifically bound to the tissue section. Subsequently slides are mounted usingDAPI/antifade and can be visualized under fluorescence microscope using appropriate filterset.
Principle	In Situ hybridization (ISH) allows the detection and localization of definitive nucleic acid sequences directly within a cell or tissue. High specificity is ensured through the action of annealing of fluorescence probe nucleic acid sequence to complementary target nucleic acid sequence. ISH techniques can be used to identify genetic aberrations like deletions, amplification, and translocationin tissue sections or within individual cells.
Storage	The BioGenex eFISH SYT Dual Color Break Apart Probe must be stored at 2-8°C protected from light and is stable through the expiry date printed on the label.

Reference	Datasheet SDS

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SKU	Supplier No.	Size	Your price	Quantity
BHR15100133	FP049-20X	20 Test	$1793		Add to Cart

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