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Home / Fish Probe

eFISH ETV6 Dual Color Break Apart P

SKU : BHR15100196

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BioGenex Laboratories

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Mfr.No.	FP083-10X
Gene Name	ETV6
Fluorophore	Orange/Green
Chromosome	12
Intended Use	The BioGenex eFISH ETV6 Dual Color Break Apart Probe is currently available forResearch use onlyeFISH ETV6 Dual Color Break Apart Probe is designed to be used forthe detection of translocations involving the ETV6 gene at 12p13.2 in formalin-fixed,paraffinembedded tissue or cells by fluorescence in situ hybridization (FISH).eFISH BioGenex ETV6 Dual Color Break Apart Probe in hybridization buffer. The probecontains green-labeled polynucleotides (Green: excitation at 503 nm and emission at 528nm, similar to FITC), which target sequences mapping in 12p13.2 proximal to the ETV6gene, and orange-labeled polynucleotides (Orange: excitation at 547 nm and emission at572 nm, similar to rhodamine), which target sequences mapping in 12p13.2 distal to theETV6 gene.
Description	Fluorescence in situ hybridization (FISH) is a robust technique of cytogenetic used for thedetection of chromosomal aberrations, presence or absence of specific DNA sequence innative context. In this technique florescent probes bind to the target sequence of DNA inchromosome. High specificity and sensitivity coupled rapid and an accurate result hasproven role of FISH in both research and diagnosis of solid tumor and hematologicalmalignancies. As technique of cancer cytogenetics, FISH, can be used to identify geneticaberrations viz., deletions, amplification and translocation in tissue sections or within individual cells. FISH is also used for use in genetic counseling, medicine, and speciesidentification. FISH can also be used to detect and localize specific RNA targets in cells,circulating tumor cells, and tissue samples1,2,3,4,5.In FISH procedure, fixed tissue sections are pretreated to expose target DNA or mRNAsequences. An appropriately labeled probe is hybridized to the exposed target DNA ormRNA sequences in the cells. Subsequent stringent washing steps remove any probe thatis non-specifically bound to the tissue section. Subsequently slides are mounted usingDAPI/antifade and can be visualized under fluorescence microscope using appropriate filterset.
Principle	In Situ hybridization (ISH) allows the detection and localization of definitive nucleic acidsequences directly within a cell or tissue. High specificity is ensured through the action ofannealing of fluorescence probe nucleic acid sequence to complementary target nucleicacid sequence. ISH techniques can be used to identify genetic aberrations like deletions,amplification, and translocationin tissue sections or within individual cells.
Storage	The BioGenex eFISH BioGenex ETV6 Dual Color Break Apart Probe must be stored at2-8°C protected from light and is stable through the expiry date printed on the label.

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SKU	Supplier No.	Size	Your price	Quantity
BHR15100196	FP083-10X	10 tests	$1152		Add to Cart

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