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Home / Fish Probe

eFISH CMYC Dual Color Break Apart P

SKU : BHR15100163

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BioGenex Laboratories

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Mfr.No.	FP064-20X
Gene Name	CMYC
Fluorophore	Orange/Green
Chromosome	8
Intended Use	The BioGenex eFISH CYMC dual color break apart probe is currently available forResearch use only. eFISH CYMC dual color break apart probeis designed to be used forthe detection of translocations involving the CMYC gene at 8q24 in formalin-fixed,paraffin embedded tissue or cells by fluorescence in situ hybridization (FISH)BioGenex eFISH CYMC dual color break apart probecomes in hybridization buffer. Theprobe contains green-labeled polynucleotides (Green: excitation at 503 nm and emissionat 528 nm, similar to FITC), which target sequences mapping in 8q24 distal to the CMYCgene, and orangelabeled polynucleotides (Orange: excitation at 547 nm and emission at572 nm, similar to rhodamine), which target sequences mapping in 8q24 proximal to theCMYC gene
Description	Fluorescence in situ hybridization (FISH) is a robust technique of cytogenetic used for thedetection of chromosomal aberrations, presence or absence of specific DNA sequence innative context. In this technique florescent probes bind to the target sequence of DNA inchromosome. High specificity and sensitivity coupled rapid and an accurate result hasproven role of FISH in both research and diagnosis of solid tumor and hematologicalmalignancies. As technique of cancer cytogenetics, FISH, can be used to identify geneticaberrations viz., deletions, amplification and translocation in tissue sections or withinindividual cells. FISH is also used for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific RNA targets in cells,circulating tumor cells, and tissue samples1,2,3,4,5.In FISH procedure, fixed tissue sections are pretreated to expose target DNA or mRNAsequences. An appropriately labeled probe is hybridized to the exposed target DNA ormRNA sequences in the cells. Subsequent stringent washing steps remove any probe thatis non-specifically bound to the tissue section. Subsequently slides are mounted usingDAPI/antifade and can be visualized under fluorescence microscope using appropriate filterset.
Principle	In Situ hybridization (ISH) allows the detection and localization of definitive nucleic acidsequences directly within a cell or tissue. High specificity is ensured through the action ofannealing of fluorescence probe nucleic acid sequence to complementary target nucleicacid sequence. ISH techniques can be used to identify genetic aberrations like deletions,amplification, and translocationin tissue sections or within individual cells.
Storage	The BioGenex eFISH CYMC dual color break apart probemust be stored at 2-8°Cprotected from light and is stable through the expiry date printed on the label.

Reference	Datasheet SDS

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SKU	Supplier No.	Size	Your price	Quantity
BHR15100163	FP064-20X	20 Test	$1793		Add to Cart

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