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Home / Fish Probe

eFISH CCND1/CEN 11 Dual Color Probe

SKU : BHR15100161

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BioGenex Laboratories

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Mfr.No.	FP063-20X
Gene Name	CCND1/CEN 11
Fluorophore	Orange/Green
Chromosome	11
Intended Use	The BioGenex eFISH CCND1/CEN 11 dual color probeis currently available for Research use only. eFISH CCND1/CEN 11 dual color probeis designed to be used for the detection of the human CCND1 gene as well as chromosome 11 alpha-satellites in formalin-fixed paraffin-embedded tissue or cells by fluorescence in situ hybridization (FISH) BioGenex eFISH CCND1/CEN 11 dual color probecomes in hybridization buffer. The probe contains green-labeled polynucleotides (Green: excitation at 503 nm and emission at 528 nm, similar to FITC), which target the CCND1 gene, and orange-labeled polynucleotides (Orange: excitation at 547 nm and emission at 572 nm, similar to rhodamine), which target alphasatellite-sequences of the centromere of chromosome 12
Description	Fluorescence in situ hybridization (FISH) is a robust technique of cytogenetic used for the detection of chromosomal aberrations, presence or absence of specific DNA sequence in native context. In this technique florescent probes bind to the target sequence of DNA in chromosome. High specificity and sensitivity coupled rapid and an accurate result has proven role of FISH in both research and diagnosis of solid tumor and hematological malignancies. As technique of cancer cytogenetics, FISH, can be used to identify genetic aberrations viz., deletions, amplification and translocation in tissue sections or within individual cells. FISH is also used for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific RNA targets in cells, circulating tumor cells, and tissue samples1,2,3,4,5.In FISH procedure, fixed tissue sections are pretreated to expose target DNA or mRNAsequences. An appropriately labeled probe is hybridized to the exposed target DNA ormRNA sequences in the cells. Subsequent stringent washing steps remove any probe thatis non-specifically bound to the tissue section. Subsequently slides are mounted usingDAPI/antifade and can be visualized under fluorescence microscope using appropriate filterset.
Principle	In Situ hybridization (ISH) allows the detection and localization of definitive nucleic acidsequences directly within a cell or tissue. High specificity is ensured through the action ofannealing of fluorescence probe nucleic acid sequence to complementary target nucleicacid sequence. ISH techniques can be used to identify genetic aberrations like deletions,amplification, and translocationin tissue sections or within individual cells.
Storage	The BioGenex eFISH CCND1/CEN 11 dual color probe must be stored at 2-8°Cprotected from light and is stable through the expiry date printed on the label.

Reference	Datasheet SDS

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SKU	Supplier No.	Size	Your price	Quantity
BHR15100161	FP063-20X	20 Test	$1793		Add to Cart

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