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Home / Fish Probe

eFISH AML1/ETO Dual Color Dual FUSI

SKU : BHR15100178

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BioGenex Laboratories

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Mfr.No.	FP072-10X
Gene Name	AML1/ETO Dual
Fluorophore	Orange/Green
Chromosome	8
Intended Use	The BioGenex eFISH AML1/ETO dual color dual fusion probe is currently available forResearch use only.eFISH AML1/ETO dual color dual fusion probe is designed to beusedfor the detection of the translocationt(8;21)(q22;q22) in formalin-fixed,paraffinembeddedtissue or cells by fluorescence in situhybridization (FISH).BioGenex eFISH AML1/ETO dual color dual fusion probe comesin hybridization buffercontains green-labeled polynucleotides(Green: excitation at 503 nm and emission at528nm, similar to FITC), which target the AML1gene in 21q22, and orange-labeledpolynucleotides(Orange: excitation at 547 nm andemission at 572 nm, similar torhodamine), whichtarget the ETO gene in 8q22.
Description	Fluorescence in situ hybridization (FISH) is a robust technique of cytogenetic used for thedetection of chromosomal aberrations, presence or absence of specific DNA sequence innative context. In this technique florescent probes bind to the target sequence of DNA inchromosome. High specificity and sensitivity coupled rapid and an accurate result hasproven role of FISH in both research and diagnosis of solid tumor and hematologicalmalignancies. As technique of cancer cytogenetics, FISH, can be used to identify geneticaberrations viz., deletions, amplification and translocation in tissue sections or within individual cells. FISH is also used for use in genetic counseling, medicine, and speciesidentification. FISH can also be used to detect and localize specific RNA targets in cells,circulating tumor cells, and tissue samples1,2,3,4,5.In an FISH procedure, fixed tissue sections are pretreated to expose target DNA or mRNAsequences. An appropriately labeled probe is hybridized to the exposed target DNA ormRNA sequences in the cells. Subsequent stringent washing steps remove any probe thatis non-specifically bound to the tissue section. Subsequently slides are mounted usingDAPI/anti-fade and can be visualized under fluorescence microscope using appropriate filterset.
Principle	In Situ hybridization (ISH) allows the detection and localization of definitive nucleic acidsequences directly within a cell or tissue. High specificity is ensured through the action ofannealing of fluorescence probe nucleic acid sequence to complementary target nucleicacid sequence. ISH techniques can be used to identify genetic aberrations like deletions,amplification, translocationin tissue sections or within individual cells.
Storage	The BioGenex eFISH AML1/ETO dual color dual fusion probe must be stored at 2-8°C protected from light and is stable through the expiry date printed on the label.

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SKU	Supplier No.	Size	Your price	Quantity
BHR15100178	FP072-10X	10 tests	$1152		Add to Cart

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