The ABL probe was labeled with orange red dye and the green dye was used to mark the BCR probe. In situ hybridization technique could be used to combine the two probes into the target detection site.
Description
Lymphatic hematopoietic system tumor
Clinical Significance
BCR/ABL fusion gene is a common cytogenetic anomaly in patients with chronic myelocytic leukemia (CML). The BCR/ABL fusion gene can be found in 90% of the CML patients. The prognosis of patients with BCR/ABL fusion gene is poor. It is clinically possible to use the BCR/ABL fusion gene to selectively use the molecular targeted therapeutic drugs . In addition, clinicians can combine other signs of patients to identify patients more effectively.