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Home / VECTOR &VIRUS / AAV Virus

eSYN promoter driven saCas9/CRISPR AAV AAV (AAV-eSYN-saCas9)

SKU : BHV21600530

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Vector Biolabs

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Description
Review(s)

Mfr.No.	7126
Description	Cas9 is the nuclease guided by the crRNA and tracrRNA (or trans-activating crRNA) to cleave specific DNA sequences. A guide RNA (gRNA) can be designed to include a hairpin that mimics the tracrRNA-crRNA complex. Binding specificity is based on the gRNA and a three nucleotide NGG sequence called the protospacer adjacent motif (PAM) sequence. With its ease in designing guide sequences to target specific genomic loci, the CRISPR/Cas system is a much simpler, faster, and robust alternative to TALEN and Zinc finger nuclease platforms.The Cas9 from Streptococcus pyogenes SF370 (SpCas9) is too big to be packaged into AAV for most promoters, and there's no extra room for including a sgRNA in the same payload with spCas9 in AAV. A small Cas9 from Staphylococcus aureus subsp. aureus (SaCas9) with high efficiency for cleaving mammalian endogenous DNA is the ideal solution to package into AAV along with sgRNA for effective gene modification in vivo.This is an AAV-DJ (a synthetic serotype made from 8 wild type AAV including AAV2, 4, 5, 8, 9) expressing saCas9 nuclease under a neuronal specific eSYN promoter. The eSYN is a hybrid promoter consisting of a 0.4Kb CMV enhancer (e) and the 0.45Kb human Synapsin I promoter fragment (SYN). eSYN promoter provides 2-4 fold higher expression than that of the parental hSYN1 promoter. This AAV-eSYN-saCas9 can be package into other AAV serotypes upon request.We also offer custom production service to package AAV-eSYN-saCas9 with your sgRNA in the same AAV virus. Please contact us for detail.
Categories	AAV, Over-Expression, CRISPR/Cas9
Product Type	Pre-Made
Virus Type	AAV
Function	CRISPR/Cas9
Promoter	eSYN ()
Storage Buffer	PBS/5% Glycerol
Viral Backbone	Recombinant AAV
Shelf Life	12 Months
HS Code	3822190000
UNSPSC Code	41106621
Insert Gene	saCas9
Availability	Ready to Ship
Titer	1x10^13 GC/ml
ITRs	AAV2

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SKU	Supplier No.	Size	Your price	Quantity
BHV21600530	7126	50 µL	$495		Add to Cart

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