IdeS Protease (40U/uL)

IdeS Protease, full name Immunoglobulin G-degrading enzyme of Streptococcus pyogenes, IdeS, is a cysteine protease produced and secreted extracellularly by the human pathogen Streptococcus pyogenes. This proteinase has extremely high substrate specificity, only recognizing IgG and cleaving at a specific site in the antibody's hinge region, resulting in the hydrolysis of IgG into intact F(ab’)2 fragments and Fc fragments. IdeS can recognize human and various other animal sources of IgG, such as human, rabbit, monkey, sheep, and human-animal chimeric IgG, etc. IdeS has unique substrate selectivity and can be used as a tool enzyme for structural characterization analysis of antibody drugs or antibody-fusion protein drugs.

This product is recombinantly expressed in E. coli, with high purity and good enzymatic activity, making it a valuable tool for characterizing therapeutic antibodies, Fc fusion proteins, and antibody-drug conjugates.

Features

High Specificity — Single cleavage site: CPAPELLG/GPSVF.

Fast Reaction — 30 minutes rapid cleavage, significantly faster than papaya proteinase and pepsin.

High Stability — Each batch of product undergoes strict quality control to ensure batch-to-batch stability.

Simple Reaction Conditions — Compatible with various pH buffer solutions, no need for reducing agents or auxiliary reagents.

Applications

IdeS enzyme is used as a tool enzyme in the preparation and structural characterization analysis of antibody drugs.

IdeS enzyme can also assist in drug development in certain fields.

Specifications

Components

Shipping and Storage

The products can be stored at -15? ~ -25? for one year.

Documents:

Safety Data Sheet

20412_MSDS_HB241219_EN

Manuals

20412_Manual_HB241219_EN

Citations & References: 

[1